At high enough temperature and/or density, matter is predicted to go through a phase transition to a new state where the quarks and gluons are deconfined, the so-called Quark-Gluon Plasma. High-energy heavy-ion collisions provide an excellent tool to produce this new state of matter in the laboratory. I will discuss the use heavy-quarks particles, with particular focus on D and B mesons, as a probe for the Quark-Gluon Plasma properties.