The fundamental constants of nature must fall within a range
of values in order for the universe to develop structure and support life. This talk outlines the current constraints on these quantities and assesses the degree of tuning required for the universe to be viable. In the realm of particle physics, the relevant parameters are the strengths of the fundamental forces and the particle masses. Additional astrophysical parameters include the cosmic energy density, the cosmological constant, the abundances of baryons and dark matter, and the amplitude of primordial density fluctuations. These quantities are constrained by the need for the universe to live for a long time, emerge from its early epochs with an acceptable chemical composition, and successfully produce galaxies. On smaller scales, stars and planets must be able to form and function. The stars must have sufficiently long lifetimes and hot surface temperatures. We also consider potential fine-tuning related to the triple alpha reaction
that produces carbon, the case of unstable deuterium, and the
possibility of stable diprotons. For all of these issues, the goal is to delineate the range of parameter space for which universes can remain habitable. In spite of its biophilic properties, our universe is not optimized for the emergence of life, in that favorable variations could result in more galaxies, more stars, and potentially more habitable planets.