I will present our newly developed DREENA framework, which allows predicting energy loss of high pt partons traversing quark gluon plasma (QGP). The framework is based on dynamical energy loss formalism, and is applied to both the medium with constant temperature (DREENA-C) and to evolving medium modeled by Bjorken 1+1D expansion (DREENA-B). The formalism allows to generate predictions for both light and heavy flavor observables, for different centralities and collision energies, as well as different experiments and collision systems. Accordingly, I will first show that our post-dictions agree well with a wide range of data at different centralities. Furthermore, I will show that the predictions, which were published well before the data became available, agree very well with these data, again explaining some of the experimentally observed, but intuitively unexpected, suppression patterns. I will also propose a new observable, which allows clearly distinguishing between different energy loss mechanisms, as well as numerical predictions and simple scaling arguments that support this proposal. The first steps in our work towards the application of this model as a novel high-precision tomographic tool of QGP medium, will also be discussed.