MLL-Kolloquium: Prof. Peter Dendooven (KVI-Center for Advanced Radiation Technology and Univ. of Groningen, the Netherlands): Positron Emission Tomography for real-time verification during proton therapy

Lecture Hall (ground floor, west) (LMU building, Am Coulombwall 1, Garching)

Lecture Hall (ground floor, west)

LMU building, Am Coulombwall 1, Garching


In comparison to photon radiotherapy, proton beam radiotherapy generally results in a lower radiation dose to normal tissue, reducing long-term complications and increasing the quality of life of patients. However, the dose distribution delivered during proton therapy is quit e sensitive to anatomical changes in the patient, proton range uncertainties and treatment errors. Because of this, several techniques for in-vivo dose delivery verification have and are being developed. We are investigating positron emission tomography (PET) of 12N produced by the proton beam in the patient. The very short half-life of 12N (11 ms) enables quasi real time feedback and precludes biological washout. I will report on recent proof-of-principle demonstrations, showing measurements of the range of 12N production by 150 MeV protons in PMMA targets with a precision of 2.7 resp. 0.9 mm for 10^8 resp. 10^9 protons. These results will be extrapolated to an optimized clinical PET setup. Finally, the roadmap towards clinical implementation will be outlined.

Organized by

Peter Thirolf (LMU) / Norbert Kaiser (TUM)

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