Garchinger Maier-Leibnitz-Kolloquium: Proton minibeam and FLASH therapy - novel tumortherapy concepts using spatial and temporal fractionation

by Prof. Judith Reindl (Univ. der Bundeswehr, Muenchen)




Proton minibeam radiotherapy (pMBRT) is an external beam radiotherapy method with reduced side effects by taking advantage of spatial fractionation in the normal tissue. This concept was developed for better sparing of normal tissue in the entrance channel of radiation. Due to scattering, the delivered small beams widen in the tissue ensuring a homogeneous dose distribution in the tumor. Preclinical in-vivo experiments conducted with pMBRT in mouse ear models or in rat brains support the prospects. A further newly emerging therapy method is FLASH radiotherapy, i.e. the treatment using ultra-high dose rates of ≥ 40 Gy/s, which has been shown to reduce radiation toxicity in normal healthy tissues with similar tumor control efficiency as conventional dose rate irradiation in pre-clinical models. Already first patients are treated using FLASH therapy, as conventional therapy stations are able to deliver such high-dose rates. Nevertheless principal and pre-clinical studies are irreplaceable to be able to fully exploit the beneficial effects of this new therapy method. This talk will focus on pre-clinical studies for both therapy approaches, single and in combination, done at the ion-microprobe SNAKE. Further a glimpse is given on how the future of research for modern proton radiotherapy methods could look like.

Online via ZOOM:

                   Meeting ID: 984 5733 2925
                   Passcode: 979953

Organized by

Peter Thirolf (LMU) / Norbert Kaiser (TUM)