Garchinger Maier-Leibnitz-Kolloquium: Molecular Radiotherapy and the WIDMApp project

by Dr Micol De Simoni (ISS, Istituto Superiore di Sanità, Rome, Italy)

Thursday Dec 12, 2024, 4:15 PM → 5:15 PM Europe/Berlin

Lecture hall, ground floor (west) (LMU building, Am Coulombwall 1, campus Garching)

The Molecular Radiotherapy (MRT) is based on the administration of a radiopharmaceutical that, thanks to its specificity, predominantly accumulates in diseased tissues and acts on them through the emission of ionizing radiation. The precise calculation of the absorbed dose by the tumor and healthy tissues is essential to increase therapeutic efficacy, optimize treatment planning, and establish dose-effect relationships. Additionally, there is a legislative challenge: European regulations (EU Directive 59/2013) mandate the planning and verification of treatment for all patients undergoing radiotherapy procedures, including MRT.

The WIDMApp (Wearable Individual Dose Monitoring Apparatus)  project aims to determine the specific biokinetics for each patient undergoing MRT treatment through a new approach that combines in a cutting-edge apparatus: a wearable multichannel device for in-vivo radiation detection, a Monte Carlo (MC) simulation modeling the propagation of radiation in the patient based on their CT image, and a sophisticated data analysis toolkit that takes as input the information provided by the detectors and the simulation. This talk is focused on the MRT challenges with a particular emphasis on the WIDMApp project. The results achieved so far and outline the next steps in the project’s development will be discussed.
Hybrid access via ZOOM:
https://lmu-munich.zoom.us/j/98457332925?pwd=TWc3V1JkSHpyOTBPQVlMelhuNnZ1dz09
Meeting ID: 984 5733 2925
Passcode: 979953

kolloquium-12-12-24.pdf